Samantha Who? (2007–2009)

Christina Applegate

Samantha 35 episodes, 2007-2009

Jennifer Esposito

Andrea Belladonna 35 episodes, 2007-2009

Kevin Dunn

Howard 35 episodes, 2007-2009

Melissa McCarthy

Dena 35 episodes, 2007-2009

Tim Russ

Frank 35 episodes, 2007-2009

Barry Watson

Todd 35 episodes, 2007-2009

Jean Smart

Regina Newly 35 episodes, 2007-2009

Rick Hoffman

Chase Chapman 9 episodes, 2007-2009

Stephen Rannazzisi

Seth 6 episodes, 2008-2009

Billy Zane

Winston Funk 5 episodes, 2009

Kiele Sanchez

Chloe 4 episodes, 2007-2008

Joy Osmanski

Tracy 4 episodes, 2007-2008

James Tupper

Owen 4 episodes, 2008

McKinley Freeman

Tony Dane 4 episodes, 2009

Arshad Aslam

Barista 1 episode, 2007-2008

Eliza Coupe

Willow 2 episodes, 2008

Eddie Cibrian

Kevin 2 episodes, 2007

Adam Devine

Tyler / ... 2 episodes, 2009

Dana Sorman

Barista 2 episodes, 2009

Jessica St. Clair

Valerie 1 episode, 2007

Todd Grinnell

Nathan 1 episode, 2007

William Abadie

Rene 1 episode, 2007

Ryan Carlberg

Jason 1 episode, 2007

Kelsey Lee Smith

Young Samantha 1 episode, 2007

Timothy Olyphant

Winston Funk 1 episode, 2008

Jerry O\'Connell

Craig 1 episode, 2008

Mary-Kate Olsen

Natalie 1 episode, 2008

Tony Hale

Dr. Andy Adams 1 episode, 2008

Teddy Sears

Brad 1 episode, 2008

Ryan Carnes

Brent 1 episode, 2008

Soledad Campos

Woman 1 episode, 2008

Angie Harmon

Gigi 1 episode, 2009

James Patrick Stuart

Bill Jacobs 1 episode, 2009

Christine Ebersole

Amy 1 episode, 2009

Nora Dunn

Cheryl Hainstock 1 episode, 2009

Dondré T. Whitfield

Wes Green 1 episode, 2009

John Taylor

Tommy Wylder 1 episode, 2009

Cooper Thornton

Instructor 1 episode, 2009

Johanna Braddy

Teenage Samantha 1 episode, 2007

Gerald Downey

Paul 1 episode, 2007

Brett Rickaby

AA Leader 1 episode, 2007

Rand Holdren

Ryan 1 episode, 2007

Sarah Rafferty

Kayla Kaminski 1 episode, 2008

Anthony Anderson

Rafael Grace 1 episode, 2008

Rachel Cannon

Carol 1 episode, 2008

Beth Littleford

Audrey Rhodes 1 episode, 2008

Tony Winters

Man 1 episode, 2008

Melody Butiu

Nurse 1 episode, 2008

Marsh Mokhtari

Mike 1 episode, 2008

Rebecca Wisocky

Lindsey 1 episode, 2009

Greg Cipes

Street Musician 1 episode, 2009

Florence Henderson

Loretta 1 episode, 2009

Indira G. Wilson

Photographer 1 episode, 2009

Brent Tarnol

Jason 1 episode, 2009

Robin Gwynne

Wife 1 episode, 2009

Nakia Burrise

Dr. Kerry Hall 1 episode, 2007

Sarah Spiegel

Young Woman 1 episode, 2007

Frank Maharajh

Dr. Kegoshian 1 episode, 2007

Curt Cornelius

Trey Wells 1 episode, 2007

Jagger Chase

Kid 1 episode, 2007

Reggie Jordan

Allison 1 episode, 2008

Morgan Murphy

Woman Protestor 1 episode, 2008

Phoebe Dorin

Older Woman 1 episode, 2008

Mark Ballas

Mateo Romero 1 episode, 2008

Tanya Bond

Girl 1 episode, 2008

Brian Catalano

Orderly 1 episode, 2008

Ossie Mair

Driver 1 episode, 2008

Terryn Westbrook

Fanny 1 episode, 2009

Charles C. Stevenson Jr.

Gentleman 1 episode, 2009

Stefan Marks

Detective Harp 1 episode, 2009

Barry Finkel

Funeral Director 1 episode, 2009

Joni Kempner

Russ 1 episode, 2007

Tony Jones

Police Sergeant 1 episode, 2007

Marilyn Sue Perry

Cashier 1 episode, 2007

Amanda Young

Paul\'s Wife 1 episode, 2007

Adam Jennings

Barista 1 episode, 2007

Natasha Leggero

Woman Customer 1 episode, 2008

Cybill Shepherd

Paula Drake 1 episode, 2008

Andre Ware

Mac Fresh 1 episode, 2008

Brian D. Phelan

Female Fan #2 1 episode, 2009

Mary Alyce Kania

Guy (Mugger) 1 episode, 2009

Hahn Cho

Doctor 1 episode, 2009

Kara Taitz

Bridesmaid 1 episode, 2007

Jamison Haase

Vic 1 episode, 2007

Jelynn Sophia

Angry Woman 1 episode, 2007

Jim Rash

Artist 1 episode, 2008

Annette M. Lesure

Waitress 1 episode, 2008

Gregory Franklin

Announcer 1 episode, 2008

Carla Greene

Waitress 1 episode, 2008

William Borger

Mother 1 episode, 2009

Abdoulaye NGom

African Methodist Minister 1 episode, 2009

Jackie Johnson

Jackie Johnson 1 episode, 2009

Susie Geiser

Woman 1 episode, 2009

Karlton Johnson

Policeman 1 episode, 2009

Jill Talley

AA Female Leader 1 episode, 2007

B.J. Clinkscales

Waiter 1 episode, 2007

Jonathan Schmock

Hipster 1 episode, 2008

Sayeed Shahidi

Little Boy 1 episode, 2008

Bree Condon

Mickey 1 episode, 2009

Denise Gossett

Homeless Woman 1 episode, 2009

Shulie Cowen

Dolly 1 episode, 2009

Michael Crider

Roth 1 episode, 2009

Dan Thiel

Dave 1 episode, 2007

Brandon Ford Green

Guy 1 episode, 2008

Tara Ochs

Waitress 1 episode, 2009

Terrance Christopher Jones

Teacher 1 episode, 2009

Greg Callahan

Cameron 1 episode, 2008

Miranda May

13 Year Old Dena 1 episode, 2009

J.P. Gillain

Philippe 1 episode, 2009

Ken Rudulph

Reporter 1 episode, 2009

David Trice

Baggage Service Rep 1 episode, 2009

Anna Zielinski

Ticket Agent 1 episode, 2009

Andre Johnson

Security Guard 1 episode, 2009

Larry Reitzer

Coffee shop clerk (uncredited) 2 episodes, 2008

Ron Riekki

Reality Cameraman (uncredited) 2 episodes, 2009

A.J. Dennis

Teenage Samantha #2 (uncredited) 1 episode, 2007

Aliza Pearl

Real Estate Executive (uncredited) 1 episode, 2007

Tamas Menyhart

Kissing Couple (uncredited) 1 episode, 2007

Oliver Goodwill

Man at Bar (uncredited) 1 episode, 2007

David Pearl

Doctor (uncredited) 1 episode, 2007

Jose David Acevedo

Bar Patron (uncredited) 1 episode, 2007

Joy Lofton

Lady in the Bar (uncredited) 1 episode, 2007

Katie Cieszynski

Crying Kid (uncredited) 1 episode, 2008

Gerard Sanders

Rory (uncredited) 1 episode, 2008

Bryan Keith

Valet Parker (uncredited) 1 episode, 2008

Jobeth Wagner

Emo Girl (uncredited) 1 episode, 2008

Dimitri Lekkos

Guy #1 (uncredited) 1 episode, 2008

Matthew L. Sobel

Guy #3 (uncredited) 1 episode, 2008

Troy Dudley

Taxi Driver (uncredited) 1 episode, 2008

Shauna Kae Lauritzen

Hostess (uncredited) 1 episode, 2009

Alexandra LeMosle

Bar patron (uncredited) 1 episode, 2009

Senta Burke

TSA Agent (uncredited) 1 episode, 2009

Michael A. Templeton

Roger (uncredited) 1 episode, 2009

Justin Warren Downing

Fan (uncredited) 1 episode, 2009